Browsing by Author "Michael Oyelami Ajisope"

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Modelling and optimal control analysis of Lassa fever disease
(Elsevier BV, 2020) Olumuyiwa James Peter; Adesoye Idowu Abioye; Festus Abiodun Oguntolu; Titilayo Abimbola Owolabi; Michael Oyelami Ajisope; Abdullaziz Glabe Zakari; Timilehin Gideon Shaba
Lassa fever is a severe hemorrhagic viral infection whose agents belong to Mastomys natelensis. Generally, humans contract Lassa virus through exposure to food or household products that have been contaminated with the excreta of the infected rodents. Lassa fever is endemic in some West African countries including Nigeria. A basic model is proposed to examine the transmission of the disease. The proposed model is subjected to qualitative study via the theory of differential equations and the threshold quantity that denotes the dominant eigenvalue was derived using next-generation matrix approach. The basic model is further extended to an optimal control model with four controls namely, the fumigation of the environment with pesticide, the use of condom to prevent human to human transmission during sexual activities, early treatment and the use of indoor residual spray. The theory of optimal control was explored to establish the necessary conditions for curtailing the transmission of Lassa fever. Numerical simulation was conducted and the results showed that if the Lassa fever transmission and spread were to be reduced significantly in the endemic region, all the control measures must be taken with all seriousness.
Stability and optimal control analysis of an SCIR epidemic model
(SCIK Publishing Corporation, 2020-10-16) Olumuyiwa James Peter; Ratchada Viriyapong; Festus Abiodun Oguntolu; Pensiri Yosyingyong; Helen Olaronke Edogbanya; Michael Oyelami Ajisope
In this paper, we proposed a deterministic model of SCIR governed by a system of nonlinear differential equations. Two equilibria (disease-free and endemic) are obtained and the basic reproduction number R0 is calculated. If R0 is less than one, then the disease-free equilibrium state is globally stable i.e. the disease will be eradicated eventually. However, when R0 is greater than unity, the disease persists and the endemic equilibrium point is globally stable. Furthermore, the optimal control problem is applied into the model. The focus of this study is to determine what control method can be implemented to significantly slow the incidence of the epidemic disease, therefore we take into account various possible combinations of such three controls which are prevention via proper hygiene, screening of the infected carriers which enable them to know their health conditions and to go for early treatment and treatment of the infected individuals. The possible strategies of using combinations of the three controls on the spread of the disease, one at a time or two at a time is also discussed. Our numerical analysis of the optimal approach suggests that the best method is to incorporate all three controls in order to control the disease epidemic.