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Item In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana(Advance Research in Life Science, 2020-10) Simon, C. Mai lafiya; Sheridan, O. Kolawole; Abdulazeez, K. Adeniyi,; Bala, A. Muhammed; Abdulfatai, Ismail; Adenine, R. Alawode; Bashir, LawalThe harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepatoprotective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.Item Evaluation of the Implementation of Automotive Mechatronic Programme in Vocational Enterprise Institutions in Nigeria(International Journal of Industrial Technology Education, Engineering, Science and Education (IJITESED), 2021) Igwe, C. O.; Abdulkadir, M.; Mustafa, A.; Nma, T. N.; Aliyu, T.; Nma, Y. A.The study was designed to evaluate the implementation of automotive mechatronics programme of the Vocational Enterprise Institutions (VEIs) in Nigeria. Two research questions and two null hypotheses guided the study. A descriptive survey research design was employed for the study. The study was conducted in three VEIs offering automotive mechatronics programme in FCT Abuja and Kaduna State. A total of 90 respondents comprising of 14 administrators 32 instructors and 44 technical staff drawn from the three National Board for Technical Education accredited Vocational Enterprise Institutions offering Automotive Mechatronics Programme in Federal Capital Territory, Abuja and Kaduna State was used as a total population for the study, A structured questionnaire titled: Automotive Mechatronics Programme Evaluation Implementation Questionnaire (AMPEIQ) developed by the researchers and validated by three experts from Industrial and Technology Education Department, Federal University of Technology, Minna was used for data collected for the study. The reliability coefficient of the instrument was 0.78 using Cronbach Alpha statistics. Statistical Package for Social Science (SPSS Version 23) was used for the data analysis. Mean, standard deviation, frequency and percentage were the statistical tools used for answering research questions while ANOVA Statistics was used to analyze the null hypotheses formulated for the study at 0.05 level of significant. The findings of the study revealed among others that: the available training equipment/facilities were rarely often used and most teaching methods needed for effective implementation of automotive mechatronics programme were rarely often used. Based on the findings it was recommended that: The VEIs in FCT Abuja and Kaduna State should adhere to the NBTE minimum requirement of training equipment/facilities for the implementation of the automotive mechatronics programmes, the available training equipment/facilities in the VEIs in FCT Abuja and Kaduna State should be effectively utilized for the implementation of the automotive mechatronics programmes, the automotive mechatronics instructors/technical staff of the VEIs in FCT Abuja and Kaduna State should be encourage to adopt wide range of teaching methods in teaching automotive mechatronics.Item Awareness and Engagement with Artificial Intelligence Technologies As Predictors of Undergraduates' Readiness in Building and Woodwork Technology for Construction Practices in Benue State.(Multidisciplinary Journal of Science and Technology Education, 2025) Nule, J. S.; Upwa, F. E.; Nwokolo-Ojo, J. O.; Tar, S.; Igwe, C. O.Industrial paternalism has been a significant factor influencing the development of Vocational and Technical Education (VTE) in Benue State. This study examined the impact, challenges and strategies of industrial paternalism on VTE using a population of 431 (97 academics and 334 non-academics) VTE graduates registered with Technical Education Practitioners Association of Nigeria (TEPAN). Krejcie and Morgan table was used to arrive at a sample size of 205 respondents. A stratified sampling technique was employed to ensure a representation across different groups. A researcher developed 15 item questionnaire was validated, subjected to reliability testing using the Cronbach’s Alpha reliability technique which yielded a reliability index of 0.87. Data collected was analyzed using mean and standard deviation to answer research questions while Inferential T-test was used to test the null hypotheses. The study revealed that industrial paternalism significantly impacts on VTE development in Benue State. The study recommended that: Government should review/update policies and increase funding that reflects current labour market demands and encourage industrial paternalism in Benue State, government and relevant stakeholders should adopt incentives and public awareness campaigns to improve paternalistic policies through tax breaks and government support and government at all levels should enhance collaboration between industries and educational institutions.Item Implementation of National Board for Technical Education Curriculum in Science and Colleges in Nigeria(Annals of Technology Education Practitioners Association of Nigeria (ATEPAN), 2025) Igwe, C. O.; Ibeneme, O. T.; Nwokolo-Ojo, J. O.; Nule, J. S.Item In-silico investigation of curcumin drug-likeness, gene-targets and prognostic relevance of the targets in panels of human cancer cohorts(GSC Biological and Pharmaceutical Sciences, 2021, 14(01), 037–046, 2021) David B Oshevire; Aishatu Mustapha; Blessing U. Alozieuwa; Hassana H. Badeggi; Abdulfatai Ismail; Opeyemi N. Hassan; Peter I Ugwunnaji; Jonathan Ibrahim; Bashir Lawal; Eustace B. BerinyuDespite advancements in diagnostic and standard treatment modalities, cancer survival rate remains disappointing globally. It has however, been recognized that exploring the therapeutic properties of secondary metabolite from natural products may alleviate the problems of drug resistance and toxicity that besiege the conventional therapies, and hence improve the overall prognosis of cancer patient. To this end curcumin, a polyphenolic natural compound has been widely studied for it anticancer activities in in vitro and in vivo models. Computational technology has significantly improved the success rate of drug discovery and development, hence, it has become a widely explore tool in drug candidate identification. In this study we used computational approached to identify 12 genes that are potential druggable candidate for curcumin. The genes identified were found to be enriched in cancer and drug resistance associated signaling pathways. Interestingly, the top 3 identified genes; Microtubule-associated protein tau (MAPT), Toll-like receptor 9 (TLR9) and Tyrosyl-DNA phosphodiesterase 1 (TDP1) were observed to be over expressed in multiple cancer cohorts and were associated with poor prognoses of the patients. Curcumin has good physicochemical, bioavailability and ADMET properties. Importantly, it met the Lipinski's Rule of 5 for drug likeness and thus worthy of further in vitro and in vivo confirmation studies.Item The Effects of Abandonment of Projects in Plateau State, Nigeria(International Journal of Engineering Research and Development, 2021) Alaezi, J.O.; Rugu, E.A.; Marut, J.J.; Igwe, C.O.Public Project particularly infrastructural projects are intended to provide new products and services to the community and at the same time promote the beauty of the environment however, their abandonment has led to so many negative effects. The study has determined the effects of abandonment of projects in plateau state, Nigeria. Quantitative method of data collection was employed in the study using close ended questionnaire. The data analysis tool that was employed for this study is the relative importance index (R.I.I). The RII was used to analyzed data obtained for the effects of abandonment of projects; the highest value of RII was ranked 1 and so on. Also descriptive statistics was employed to analyze the background of the respondents. It has been discovered from the research that, project abandonment has at least (15) far-reaching effects on national development. Cost overrun which was ranked first (1 ) with 91.00% is a very significant effect of project st abandonment, when projects are abandoned it leads to increase in the initial cost of the project, the final cost of the project will be exceeded leading to the initial cost of the project as a result of non-completion of projects within the agreed contract period. Other effects of project abandonment include: discouragement of investment is 89.00%, wastage of expended resources 88.00%, affects economic growth 86.00%, leads to unemployment 85.00%, hide out for criminals 83.00%, time overrun 82.00%, disappointment to the prospective users 81.00%, increase risk and project becomes obsolete and affects the aesthetics of the built environment 80.00%, affects quality 79.00% and reduces revenue 79.00%, technological backwardness 78.00% and finally reduces standard of living with 72.00%. It can be inferred that project abandonment has great effect on costItem A Review of Alternative Building Materials for Sustainable Construction Towards Sustainable Development(2021-01-19) Johnson Josiah Marut; John Okwe ALAEZI; Igwe Christopher OBETAThe study reviewed Alternative Building Materials for sustainable construction towards sustainable development. The study was able to identify some Alternative Building Materials, their features, classes (types), and importance for sustainable construction toward sustainable development. The study uses a systematic literature review and content analysis. Some of the Alternative Building Materials include laterite soil, brick wastes, rice husk ash burnt refuse ash, fly ash, periwinkle shell powder, earthworm cast, pulverized burned clay, periwinkle shell aggregate, tubali, earth/mud blocks or bricks, laterite blocks, bamboo for roofing & ceiling, palm front roofing, clay/mud plaster. The classes of the Alternative Building Materials include: modified conventional industrial materials, unconventional/ indigenous/ traditional materials, and modified unconventional/traditional indigenous materials. The features of sustainable construction materials include recyclability, insulation and thermal conductivity and deconstruct ability, availability, manufacturing and price, flexibility and high life time expectancy. The importance of Alternative Building Materials includes: the protection of the environment through reduce energy use and also cutting down CO2 emission, provision of affordable housing, energy conservation, meeting increasing demands for housing stock, provision of employment opportunities, the development and propagation of indigenous technological ingenuity and skills of our local people. The study advocates for the integration of the entire stakeholders in the construction industry towards utilisation of Alternative Building Materials for sustainable construction towards sustainable development. The study also advocates for the cataloguing of all Alternative Building Materials so as to create awareness to all the potential clients and stakeholders of the industry regarding their availability and importance.Item Stability Analysis of Rotavirus Model with Co-infection and Control Measures(Journal of Science, Technology, Mathematics and Education, 2021-06) R. O. Olayiwola; F. A. Kuta; F. A. Oguntolu; O. N. Emuoyibofarhe; F. T. OlayiwolaA mathematical model of the spread of rotavirus diarrhea based on a continuous time ordinary differential equation modeled two viral strains of influenza is presented. The existing influenza models is extended to include the case of co-infection when a single individual is infected with both strains of rotavirus and to explore the effects of maternal antibodies, vaccination and seasonality. The model exhibits two equilibria, disease-free equilibrium (DFE) and the endemic equilibrium (EE). Equilibrium analysis is conducted in the case with constant controls for both epidemic and endemic dynamics. By the use of Lyapunov function, it is shown that if the effective reproduction number, R0<1, the DFE is globally asymptotically stable and in such a case, the EE is unstable. Moreover, if R0 >1, the endemic equilibrium is globally asymptotically stable.Item A Mathematical Model Analysis of Meningitis with Treatment and Vaccination in Fractional Derivatives(Springer Science and Business Media LLC, 2022-04-26) Olumuyiwa James Peter; Abdullahi Yusuf; Mayowa M. Ojo; Sumit Kumar; Nitu Kumari; Festus Abiodun OguntoluIn this paper, we develop a new mathematical model based on the Atangana Baleanu Caputo (ABC) derivative to investigate meningitis dynamics. We explain why fractional calculus is useful for modeling real-world problems. The model contains all of the possible interactions that cause disease to spread in the population. We start with classical differential equations and extended them into fractional-order using ABC. Both local and global asymptotic stability conditions for meningitis-free and endemic equilibria are determined. It is shown that the model undergoes backward bifurcation, where the locally stable disease-free equilibrium coexists with an endemic equilibrium. We also find conditions under which the model’s disease-free equilibrium is globally asymptotically stable. The approach of fractional order calculus is quite new for such a biological phenomenon. The effects of vaccination and treatment on transmission dynamics of meningitis are examined. These findings are based on various fractional parameter values and serve as a control parameter for identifying important disease-control techniques. Finally, the acquired results are graphically displayed to support our findings.Item Modeling the impact of control strategies on malaria and COVID-19 coinfection: insights and implications for integrated public health interventions(Springer Science and Business Media LLC, 2023-12-27) Adesoye Idowu Abioye; Olumuyiwa James Peter; Emmanuel Addai; Festus Abiodun Oguntolu; Tawakalt Abosede AyoolaThis work discusses the challenge posed by the simultaneous occurrence of malaria and COVID-19 coinfection on global health systems. We propose a novel fractional order mathematical model malaria and COVID-19 coinfection. To assess the impact of control strategies on both diseases, we consider two control strategies which are, personal protection against mosquito bites ($$u_{1}(t)$$) and preventive measures for COVID-19 ($$u_{2}(t)$$). Numerical simulations demonstrate that consistent application of these measures leads to significant reductions in disease transmission. Using insecticide-treated nets and repellents during day and night effectively reduces malaria transmission, while implementing facial masks and hand hygiene controls COVID-19 spread. The most substantial impact is observed when both sets of protection measures are simultaneously adopted, highlighting the importance of integrated strategies. The study provides valuable insights into malaria and COVID-19 coinfection dynamics and emphasizes the impact of the control measures. of individual behavior and consistent adoption of personal protection measures to control both diseases. It underscores the need for integrated public health interventions to combat the dual burden of malaria and COVID-19, contributing to the development of targeted and efficient control measures.